CRP and dengue disease: In the context of the two-hit model for dengue severity, these proteomic shifts could represent the “first hit” of viremia-induced inflammation (e.g., acute-phase CRP elevation), primed by cross-reactive anti-SARS-CoV-2 antibodies in dual exposures, setting the stage for a “second hit” of autoantibody-mediated damage during the critical phase (41).