C3 and dengue disease: Notably, proteins associated with dengue severity, such as C1q and C3 from the complement system, CRP as an acute-phase reactant (64, 65), indicators of hypoalbuminemia (66), and downregulation of apolipoproteins (APOA1 and APOB) (67) were consistently altered across the infected groups, particularly in the NS1/SARS_IgG and NS1/DENV_IgG groups.