TGFB1 and Thrombocytopenia: For example, the NS1/SARS-DENV_IgG group’s enrichment in complement/coagulation pathways (p = 0.016) and TGF-β signaling (p = 0.022) corresponded clinically to their milder thrombocytopenia (16.6%) and absence of hematocrit abnormalities, consistent with a Th2-skewed, non-hemorrhagic phenotype.