Thrombospondin-1 (THBS1), released from α-granules of activated platelets, points to aggregation and consumption, correlating with thrombocytopenia, bleeding, plasma leakage, and organ failure in severe dengue (57), peaking critically (days 3–4 post-infection) and resolving post-convalescence (58). Here, THBS1 is linked to dengue disease.