ZIP6 (LIV-1) has subtype-specific roles; in estrogen receptor-positive (ER+) cancers, STAT3 transactivates it to induce zinc-mediated EMT via GSK-3β inhibition and Snail stabilization (9), whereas its surface overexpression in triple-negative breast cancer (TNBC) predicts poor prognosis and identifies it as a target for ADCs (194). The gene discussed is SLC39A6; the disease is cancer.