In gastrointestinal malignancy, zinc transporters are found to be altered with specific pathologic implications; ZIP4 serves as an oncoprotein in pancreatic cancer, gastric cancer, and hepatocellular carcinomas by inducing EMT, chemoresistance, and cachexia (73–75), while the expression of SLC30A1 and SLC39A6 is associated with poor prognosis (76–79). This evidence concerns the gene SLC39A4 and pancreatic neoplasm.