SLC39A4 and cancer: Mechanistically, ZIP4 promotes metastasis and EMT by upregulating the ZEB1/YAP1-ITGA3 axis and silencing ZO-1/Claudin-1 (73, 178), induces gemcitabine resistance by silencing ENT1 via ZEB1 (74), and promotes cancer cachexia by releasing vesicles via RAB27B (75).