Using MARCO-deficient mice, they demonstrated that these periportal macrophages play a protective role—in chronic colitis-induced PSC-like cholangitis/fibrosis and in MCD + high-fat diet-induced MASH, loss of this MARCO+ macrophage population led to the exacerbation of inflammation and fibrosis specifically in periportal regions (35). The gene discussed is MARCO; the disease is cholangitis.