Recurrent URTI and LRTI, bronchiectasis, Addison’s disease, dysgammaglobulinemia, ↓CD19+ B cells, inverted CD4/CD8 ratio, ↑CD8+CD45RA+CD27- TEMRA cells, abnormal CD4+CD45RA/RO ratio. The gene discussed is CD27; the disease is dysgammaglobulinemia.