QSG promotes the transition of macrophages from the M1 to M2 phenotype, inhibits the activation of the NLRP3 inflammasome, and subsequently suppresses the activation of the P2X7R-NEK7-NLRP3 pathway. This reduces the release of pro-inflammatory factors, alleviates myocardial ischemia/reperfusion injury, and improves cardiac function and repair after AMI. The gene discussed is NEK7; the disease is myocardial ischemia.