“Classical” M1-like macrophages, primed by interferon-γ (IFN-γ) and microbial products such as lipopolysaccharide, mount microbe- and tumor-directed responses characterized by robust secretion of pro-inflammatory cytokines (IL-1β, IL-6, TNF) and high output of inducible nitric oxide synthase (iNOS) and reactive oxygen species (146). Here, NOS2 is linked to neoplasm.