The gene-specific RRs for this combined outcome were 3.1 (95% CIs, 1.4–6.9) for MLH1, 3.6 (95% CIs, 1.9–6.7) for MSH2/EpCAM, 0.3 (95% CIs, 0.0-Inf) for MSH6 and 0 for PMS2. An overview of the RRs for the various cancers in individuals with LS compared to the general population is provided in Table 3. This evidence concerns the gene MLH1 and Leigh syndrome.