By age 75, the combined CI of PDAC, AC and dCC was 3.0% (95% CIs, 1.5–5.8) in MLH1, 3.4% (95% CIs, 2.0–5.8) in MSH2/EpCAM, 1.0% (95% CIs, 0.3–2.7) in MSH6 and 0% in PMS2. No familial-clustering of cancers was observed. This evidence concerns the gene PMS2 and cancer.