Anti-proliferative; apoptosis induction (↑ Bax, Bak; ↓ Bcl-2, Bcl-XL); mitochondrial dysfunction; caspase activation; lysosomal vacuolation; NF-κB/COX-2/PGE2 suppression; topoisomerase inhibition; ↓ tumor growth in vivo. The gene discussed is PTGS2; the disease is neoplasm.