IL1B and polycystic ovary syndrome: The lowest IL-1β concentrations was noted in the combined therapy group - PCOS + melatonin + metformin [109.30 (106.80-210.90) pg/mL], and it was significantly lower compared to in the PCOS + metformin group [165.0 (115.75-886.87) pg/mL] (p=0,026) and PCOS + melatonin group [124.0 (114.55-431.10) pg/mL] (p=0,041) (Figure 4).