Given the patient's history of the genetic mutation, we propose that her recurrent osteomyelitis, infectious subglottic stenosis, and medically treated hypoglycemia are correlated to her pathogenic heterozygous HYOU1 mutation (exon 23, c.2638G>A) (p.Ala880Thr). The gene discussed is HYOU1; the disease is Subglottic stenosis.