This elevated index likely reflects several methodological factors: (i) exclusive inclusion of SMA cases with predominant plexiform pattern, known for robust peripheral proliferation in ameloblast-like cells; (ii) strict hotspot selection at ×100 magnification to identify maximal staining density; (iii) counting of 1,000 tumor epithelial nuclei per case at ×400; and (iv) use of a highly sensitive ready-to-use MIB-1 antibody. This evidence concerns the gene SMN1 and neoplasm.