PH - pulmonary hypertension; CTD - connective tissue disease; CHD - congenital heart disease; ERA - endothelin receptor antagonist; PDE5i - phosphodiesterase-5 inhibitor; PGI2 - prostacyclin analogue; sGC stim - soluble guanylate cyclase stimulator; CCB - calcium channel blocker; PAH - pulmonary arterial hypertension; COPD - chronic obstructive pulmonary disease; ILD - interstitial lung disease; CKD - chronic kidney disease. The gene discussed is SGCB; the disease is chronic obstructive pulmonary disease.