HF, heart failure; HFmrEF, heart failure with mildly reduced ejection fraction; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal pro-BNP; PASP, pulmonary artery systolic pressure; TTE, transthoracic echocardiography. This evidence concerns the gene NPPB and hydrops fetalis.