Univariate analysis using log-rank/Cox PH identified several variables significantly associated with 28-day mortality, including age (P = 0.006), history of stroke (P = 0.004), coronary artery disease (P = 0.011), lactate (P < 0.001), hemoglobin (P = 0.002), hematocrit (P = 0.036), RDW (P < 0.001), albumin (P < 0.001), RAR (P < 0.001), APACHE II score (P < 0.001), SOFA score (P < 0.001), CCI score (P = 0.007) (Table 3). This evidence concerns the gene ALB and Stroke.