Preventive orthopedics integrates risk stratification; neuromuscular and ergonomic interventions; lifestyle-first osteoarthritis management; fall and fracture prevention, including osteoporosis screening and fracture liaison services; workplace MSK programs; perioperative prehabilitation; digital health technologies; and emerging pharmacologic strategies such as glucagon-like peptide-1 (GLP-1)-based weight management. The gene discussed is GCG; the disease is osteoarthritis.