Observation: 3, 6, 12 h. Survival: mortality lower in dexamethasone vs model; Pancreatitis severity: pathology and serum amylase; Inflammation/oxidative stress: Bax, NF‐κB, TLR‐4, ICAM‐1, TUNEL staining. The gene discussed is TLR4; the disease is pancreatitis.