Observation: 0.5, 2, 6, 12 h. Pancreatitis severity: pathology confirmed ANP (hemorrhage, edema, necrosis), lung injury assessed; Microcirculation: lung perfusion by radioactive microspheres (90mTc‐labeled RBCs); Hemostasis: TXA2/PGI2 ratio; Inflammation: serum PLA2 activity. The gene discussed is NPPA; the disease is pancreatitis.