COG1 and Global developmental delay: Mutations of COG1 leads to COG1-CDG, causing facial dysmorphism, developmental delays, intellectual disability, seizures and other health problems, reflecting abnormal hepatic, gastrointestinal, skeletal and cardiac functioning (Wu et al., 2004; Spaapen et al., 2005; Foulquier et al., 2006; Morava et al., 2007; Zeevaert et al., 2009; Marques-da-Silva et al., 2017; Quelhas et al., 2021; Salazar et al., 2021).