Our gene-based association analysis revealed that protein-truncating variants (PTVs) in 18 genes (BLVRB, KLHL32, NEK1, RIMS2, DYDC2, DCBLD1, ANXA4, SLC44A3, ATP10A, FRAS1, COMP, TRIM42, ANO4, NFX1, CFAP206, NLRP2, CKAP2L and ANGPTL4) were significantly enriched in MND cases compared to controls (PSKAT-O < 2.5 × 10−6, Table 1). This evidence concerns the gene ANGPTL4 and mild neurocognitive disorder.