Our gene-based association analysis revealed that protein-truncating variants (PTVs) in 18 genes (BLVRB, KLHL32, NEK1, RIMS2, DYDC2, DCBLD1, ANXA4, SLC44A3, ATP10A, FRAS1, COMP, TRIM42, ANO4, NFX1, CFAP206, NLRP2, CKAP2L and ANGPTL4) were significantly enriched in MND cases compared to controls (PSKAT-O < 2.5 × 10−6, Table 1). The gene discussed is FRAS1; the disease is mild neurocognitive disorder.