Our gene-based association analysis revealed that protein-truncating variants (PTVs) in 18 genes (BLVRB, KLHL32, NEK1, RIMS2, DYDC2, DCBLD1, ANXA4, SLC44A3, ATP10A, FRAS1, COMP, TRIM42, ANO4, NFX1, CFAP206, NLRP2, CKAP2L and ANGPTL4) were significantly enriched in MND cases compared to controls (PSKAT-O < 2.5 × 10−6, Table 1). Here, CFAP206 is linked to mild neurocognitive disorder.