Our gene-based association analysis revealed that protein-truncating variants (PTVs) in 18 genes (BLVRB, KLHL32, NEK1, RIMS2, DYDC2, DCBLD1, ANXA4, SLC44A3, ATP10A, FRAS1, COMP, TRIM42, ANO4, NFX1, CFAP206, NLRP2, CKAP2L and ANGPTL4) were significantly enriched in MND cases compared to controls (PSKAT-O < 2.5 × 10−6, Table 1). Here, BLVRB is linked to mild neurocognitive disorder.