NEK1 and mild neurocognitive disorder: However, for NEK1, missense variants of different masks (AlphaMissense > 0.9, > 0.7 or > 0.6; REVEL > 0.7 or > 0.5) were significantly enriched in MND cases compared to control individuals (PSKAT-O < 2.5 × 10−6, Supplementary Table S1), highlighting the high pathogenicity of NEK1 missense variants and their significant contribution to MND pathogenesis.