Sleep disturbances associated with somatic symptoms can elevate inflammatory markers (CRP, IL-6) (Kappelmann et al., 2021; Mayer-Suess et al., 2024), contributing to vascular damage and atherosclerosis, thereby increasing stroke risk (Kong et al., 2022; Soehnlein and Libby, 2021). The gene discussed is IL6; the disease is atherosclerosis.