Autopsy studies of AD patients revealed that amyloid plaques composed of β-amyloid (Aβ) peptides and neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau protein are hallmark pathological features of the disease (Glenner and Wong, 1984; Kang et al., 1987; Grundke-Iqbal et al., 1986; Kosik et al., 1986; Kidd, 1963). This evidence concerns the gene MAPT and Alzheimer disease.