However, LRP1 expression in AD patients exhibits spatial heterogeneity: vascular endothelial LRP1 is compensatory upregulated in response to increased Aβ burden, while neuronal LRP1 is downregulated, potentially exacerbating synaptic Aβ toxicity and tau aggregation (Donahue et al., 2006; Jeynes and Provias, 2008). Here, MAPT is linked to Alzheimer disease.