Studies have found that tissue-nonspecific alkaline phosphatase (TNAP), an ecto-enzyme upregulated in the brains of AD patients, inhibits LRP1-mediated Aβ transport across the BBB and Block TNAP can enhance Aβ clearance through LRP1-mediated transport across the BBB (Soria-Tobar et al., 2024). The gene discussed is ALPL; the disease is Alzheimer disease.