Tanshinone IIA (Tan IIA) enhances LRP1 expression in both animal models and cultured cells, promoting Aβ transport by alleviating SIRT1-mediated endoplasmic reticulum (ER) stress in brain microvascular endothelial cells (BMECs) to improve cognitive deficits in APP/PS1 mice (Wan et al., 2023). This evidence concerns the gene LRP1 and Cognitive impairment.