The traditional Chinese medicine formula ZhengXingshuiYizhi Fang (XSF) has been found to inhibit Aβ-induced endothelial apoptosis via the PI3K/Akt/NF-κB pathway and restore Aβ clearance across the BBB by upregulating LRP1 expression, highlighting the potential of multi-target interventions in AD treatment (Wu L. et al., 2020). Here, LRP1 is linked to Alzheimer disease.