Based on the above, the aim of this study is to use functional data to obtain ETS, separate time points according to co-fluctuation amplitude, and construct high- and low-amplitude co-fluctuation networks to distinguish the differences in brain dynamics and network metrics between SCD and HC, and to further explore the correlations between network metrics, cognitive scores, and APOE ε4 genes. The gene discussed is APOE; the disease is Schnyder corneal dystrophy.