<h4>Objectives</h4>To explore the association of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on heart rate (HR) in overweight or obese patients without diabetes.<h4>Methods</h4>A comprehensive search of the PubMed, Web of Science, Embase, and Cochrane Library databases was conducted. This evidence concerns the gene GLP1R and diabetes mellitus.