Androgen levels in men are constant and dampen immune responsesDirectly upregulate Ptpn22 to decrease TCR strength and protect against mouse models of T1D and SLE [15]Directly modulate H3K27Me3 methylation marks near glutamine transport proteins in Th17 cells to alter metabolic pathways [16]AR enhances Treg suppressive function and increases Treg/Th2 ratio in allergic inflammation [17]AR can promote histone H4 acetylation near the Foxp3 locus [18]Androgens regulate bone marrow development of B cells through decrease BAFF [19, 20]. The gene discussed is AR; the disease is systemic lupus erythematosus.