Total IgE, eosinophils, CRP, ESR, D-dimer, and anti-TPO did not correlate with therapeutic response.<h4>Study limitations</h4>Cross-sectional study and reliance on clinical records, information bias, and selection bias.<h4>Conclusions</h4>High BMI, female gender, early symptom onset, prolonged disease duration, and mental disorders were associated with poorer response to CU treatment. This evidence concerns the gene IGHE and psychiatric disorder.