Comparison of our PTEN FISH data with p53 and p16 data from previous studies [30, 31] revealed a statistically significant association between PTEN deletions and aberrant p53 and p16 immunostaining (p < 0.0001 each) in the subset of pT2‐4 urothelial bladder carcinomas (Figure 3). Here, TP53 is linked to bladder transitional cell carcinoma.