In this way, this paper explores the alleviating effect and neuroprotective function of TH, which is the newly proposed but still controversial, on hydrocephalus post IVH, and explains the general and molecular mechanisms from the macro and micro perspectives, so that we can provide a reliable theoretical basis for the application of TH as a novel therapeutic strategy in the clinical treatment of hydrocephalus post IVH. The gene discussed is TH; the disease is Hydrocephalus.