Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated using the formula (fasting insulin [μU/mL] Å~ fasting glucose [mg/dL])/405).<h4>Results</h4>In the study, insulin and HOMA-IR levels increased significantly as the degree of obesity increased (P < .05). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.