IQGAP3 functions as a scaffolding protein, interacting with diverse structural proteins to alter cytoskeletal dynamics and intracellular signaling, thus influencing the proliferation and migration of tumors.24 IQGAP3 expression correlates with aggressive clinicopathologic features.25 Moreover, IQGAP3 promotes Epithelial-Mesenchymal Transition (EMT) and metastasis through activation of the Ras/ERK pathway and transforming growth factor and intracellular 26,27 and activation of the Wnt/EMT, and metastasis through activation of resistance in HCC cells. The gene discussed is IQGAP3; the disease is hepatocellular carcinoma.