The discovery of elevated syndecan-1 levels in acute coronary syndrome indicates a link between coronary artery disease and syndecan-1 levels.34 Two studies in children with Kawasaki disease also found higher serum syndecan-1 levels compared to healthy control children.35,36 These studies suggest that syndecan-1 levels are directly connected to cardiovascular involvement in Kawasaki patients. The gene discussed is SDC1; the disease is acute coronary syndrome.