One study in children with Immunoglobulin A (IgA) vasculitis indicated that serum syndecan-1 levels might serve as a marker for vascular endothelial damage.37 Another study involving patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis suggests that serum syndecan-1 levels could predict disease activity and overall mortality.38 Overall, when these studies are considered, the increased syndecan-1 levels in Kawasaki vascular involvement, IgA vasculitis, and ANCA-associated vasculitis imply that syndecan-1 is linked to vascular participation in vasculitic diseases. This evidence concerns the gene SDC1 and vasculitis.