RUNX2 and gout: Several miRNAs have been reported to be either upregulated or downregulated in gout, contributing to disease pathogenesis.18,19 For example, miR-3146 mediates NETs formation and may play a role in the pathogenesis of gout.18 miR-146a overexpression may downregulate IL-1β expression in MSU-induced THP-1 cells.20 Importantly, miR-23a-5p has been shown to target Runx2, which is involved in osteogenic differentiation.21 However, its role in gout-related inflammation remains unknown.