A recent study on colorectal cancer showed that miR-23a-5p could bind to P14AS to inhibit TNF-NF-κB signaling and decrease IL-6 and IL-8 levels.27 Another study suggested that miR-23a-5p agomir injection effectively reduced airway inflammation in mice with chronic obstructive pulmonary disease.28 Although in a different context, these findings support the view that miR-23a-5p regulates inflammation, consistent with its anti-inflammatory role in MSU-induced gout. The gene discussed is NFKB1; the disease is gout.