IL-17 is derived from T helper 17 (Th17) cells (a subset of CD4+ T cells) and typically plays an important role in autoimmune diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease.12 The IL-17A neutralizing antibody has recently been shown to alleviate inflammation in mice with gout.13 Additionally, multiple studies have demonstrated that IL-17A can activate NLRP3 inflammasome formation.14,15. The gene discussed is NLRP3; the disease is gout.