In conclusion, this study retrospectively analyzed the clinicopathological and prognostic data of 105 metastatic nccRCC patients at our centre, including 41 pRCC, 31 TFE3/TFEB-rearranged RCC, 26 unclassified RCC, 3 chRCC, 3 FH-RCC and 1 collecting duct carcinoma. This evidence concerns the gene TFEB and collecting duct carcinoma.