These findings with the observations in lipid metabolism regulation above‐mentioned collectively position SWI/SNF chromatin remodelers as pivotal regulators of NAFLD pathogenesis through dual mechanisms: disrupting lipid homeostasis via transcriptional imbalance between anabolic and catabolic pathways, while perpetuating sterile inflammation through cytokine‐driven microenvironment alterations. Here, SMARCA1 is linked to metabolic dysfunction-associated steatotic liver disease.