SOD2 and polycystic ovary syndrome: Moreover, superoxide dismutase 2 (SOD2), a ROS-activated mitochondrial antioxidant enzyme, was significantly upregulated in the ovaries of PCOS mice, whereas low-, high-dose BSTJF and FPS-ZM1 treatments markedly suppressed SOD2 overexpression compared to PCOS mice (all P < 0.05) (Fig. 9F).