NFKB1 and polycystic ovary syndrome: Given that RAGE is an important target of BSTJF and existing literature has demonstrated that RAGE inhibitors can ameliorate PCOS [35] and regulate the phosphorylation of p65 NF-κB and p38 MAPK signaling [38], we employed the RAGE inhibitor FPS-ZM1 as a positive control in the animal experiments.