Here, we report that DKO T<sub>H</sub>2-high carrying autoantigen-specific TCR (2D2) develop atypical spontaneous experimental autoimmune encephalomyelitis (EAE), with CD4<sup>+</sup> T cells simultaneously producing IL-4 and GM-CSF, directly causing neuroinflammation. This evidence concerns the gene CSF2 and experimental autoimmune encephalomyelitis.