Consistent with attenuated osteolysis, tartrate-resistant acid phosphatase (TRAP) staining showed decreased osteoclast activation in tumor-bearing femurs of LipoNCs@pGSDMB-treated mice (Fig. 4L), evidenced by decreased surface area and osteoclast number relative to bone surface (Fig. 4, M and N). Here, ACP5 is linked to neoplasm.