The selective induction of NNMT in glioblastoma tumors but not in contralateral brain tissue (Fig. 4, I and J) is not due to differences in drug levels or GR expression between the tissues (Fig. 4, H and L) and may reflect tumor-specific factors, such as higher baseline NNMT expression (Fig. 4, K and T) (37), chromatin accessibility, or cofactor availability. This evidence concerns the gene NR3C1 and neoplasm.