Yi et al. in a study on drug-induced hypothyroidism in mice found that hypothyroidism could reduce the thermal pain threshold through mechanisms such as up-regulating the GluR1 subunit, NR2B-containing NMDA receptors, and γ-aminobutyric acid (GABA) A receptors in the anterior cingulate cortex. The gene discussed is GRIN2B; the disease is hypothyroidism.