The induction of TSLP and IL-8 in epithelial cells in response to viral stimulation, and their interaction with Th2 cytokines in the microenvironment—particularly during viral infections in asthma—should be a focus of attention for clinicians, especially in severe asthma cases where the selection of appropriate biologic agents should be guided by the underlying pathophysiological condition. Here, TSLP is linked to viral infectious disease.