Dietary exposure to Sn occurs primarily through canned foods [13], where its organotin compound tributyltin (TBT) disrupts hypothalamic-pituitary-thyroid (HPT) axis homeostasis by acting on nuclear receptors (RXR/PPARγ), interfering with thyroid hormone synthesis, secretion, and metabolism to ultimately promote thyroid cancer [14]. Here, PPARG is linked to thyroid gland carcinoma.