Jagavelu et al. demonstrated that TLR4-mutant mice (C3H/HeJ, TLR4-MT) exhibited impaired angiogenesis in liver endothelial cells and a concomitant reduction in liver fibrosis, highlighting the pivotal role of TLR4 signaling in hepatic pathophysiology [50]. The gene discussed is TLR4; the disease is Hepatic fibrosis.