Studies have shown that microglia, invading macrophages, invading neutrophils, T cells (e.g., γδ T cells, CD8 + cytotoxic T cells, CD4 T cells and Treg cells) gradually migrate to the injured brain region after ischemic stroke, and these cells enhance or attenuate ischemic brain parenchymal damage by inducing sterile inflammation [26]. The gene discussed is CD4; the disease is ischemic stroke.