NOTCH1 and breast cancer: Different miRNAs have also been associated to BC angiogenesis such as: Let-7f (which targets TSP-1, Thrombospondin-1), miR-10b (which targets NOTCH1, Notch receptor 1) and miR-126 (which regulates Ang1, Angiopoietin-1), with pro-angiogenic properties.