VEGF signaling inhibition exacerbates hypoxia within the tumor microenvironment (TME), further stabilizes HIFs, and induces the expression of compensatory angiogenic factors such as platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and stromal-derived factor-1 (SDF-1) [7]. The gene discussed is VEGFA; the disease is neoplasm.