This was recently exemplified for Noonan syndrome [35] and cognitive impairment has been documented in the context of the following conditions: CHAT-CMS, LAMB2-CMS, SLC5A7-CMS, SNAP25-CMS, UNC13A-CMS, DPAGT1-CMS, ALG2-CMS, MYO9A-CMS, and SLC25A1-CMS [8]. Here, ALG2 is linked to Cognitive impairment.