CD47 and Alzheimer disease: When the co-localisation of AT8 + tau and CD47 within synaptosomes with AT8 + tau was compared between the Braak stages, no difference was seen between stage 0 and stage 3 or stages 3 and 6, yet the fraction of synaptosomes with CD47 and AT8 + tau co-localisation was significantly lower in stage 6 AD brains compared to the control brains (Fig. 3k).