Nevertheless, there is currently no standardized screening method for early detection of RA-associated interstitial lung disease (ILD).<h4>Purpose</h4>This study proposes using pulmonary function testing (PFT) combined with lung ultrasound (LUS) as additional and radiation-free method to screen for ILD inRF- and ACPA-positive RA patients. This evidence concerns the gene PRTN3 and interstitial lung disease.