GLP1R and type 2 diabetes mellitus: Similarly, Hoffmann et al. monitored patients with prediabetes over a year and observed that although there were no initial differences, those who developed T2DM during the study exhibited lower post-OGTT glicentin and GLP-1 stimulation, reduced postprandial glucagon suppression, and longitudinal changes in glicentin and GLP-1 AUCs that were predictive of T2DM onset [16].