TLR7 and systemic lupus erythematosus: Monogenic mutations in TLR7 in SLE patients have been reported [184, 185, 186], and a TLR7 mutation (TLR7Y264H) was recently identified in SLE patients that increases both the affinity to endogenous ligands and amplifies TLR7 signaling pathways, resulting in B cell‐mediated production of self‐antigens [192].