Perturbations NF‐κB regulation have been implicated in a wide spectrum of conditions, including autoimmunity, chronic inflammatory disorders, viral infections, cancers, and aberrant apoptosis, where constitutive activation of NF‐κB amplifies pathological inflammation, promotes malignant transformation, and alters cell death pathways [249]. The gene discussed is NFKB1; the disease is Autoimmunity.