This novel connection between NF‐κB signaling and XCI maintenance may be a factor in female‐biased autoimmune diseases such as systemic lupus erythematosus (SLE) and some rheumatic diseases, as autoimmune patient lymphocytes often exhibit aberrant NF‐κB activation and chronic inflammation [126, 127]. This evidence concerns the gene NFKB1 and systemic lupus erythematosus.