Intriguingly, while caspase‐1 triggers GSDMD‐mediated pyroptosis in various peripheral neuropathies [25, 26, 27, 28, 29, 30, 31], caspase‐1 instead activates gasdermin A (GSDMA) or gasdermin E (GSDME) in the CNS disorders [32, 33]. The gene discussed is GSDME; the disease is central nervous system disorder.