NLRP3 and hydrops fetalis: Therefore, in the current study, we aimed to characterize the levels of selected pro- and anti-inflammatory cytokines, soluble α-Klotho protein and complete blood count (CBC) in patients with HF and adequate high-voltage therapy with ICD/CRT-D as a result of VAs, to determine their possible impact on the occurrence of device shocks focusing on, among others, the NLRP3 inflammasome and the Klotho protein, which are currently one of the most intensively studied target in molecular cardiology.