Right now many studies have presented that therapy with inhibition of pro-inflammatory cytokines such as IL-1 or IL-18 has promise as a new direction for the treatment of HF and may cause increased oxygen consumption, may improve exercise tolerance and may reduce cardiac fibrosis (Buckley et al., 2018; Mallat et al., 2004; van Tassell et al., 2012). This evidence concerns the gene IL18 and hydrops fetalis.