Moreover, inhibition of NLRP3 inflammasome slowed the HF process in animal model, can reduce myocardial fibrosis, delay the development of HF after myocardial infarction and the knockout of NLRP3 may reduce macrophage accumulation, which attenuated the inflammatory response and the development of fibrosis during HF (Wang et al., 2023). The gene discussed is NLRP3; the disease is Myocardial fibrosis.