IL6 and COVID-19: Higher cytokine level, especially interleukin 6 (IL-6) independently increased the risk of ICD shocks and is a predictor of SCD, however, data from the period of the COVID-19 pandemic (a systemic inflammatory disease) are not clear (Adabag et al., 2021; Cheng et al., 2014; Jagielski et al., 2018; Lazzerini et al., 2022; Streitner et al., 2009).